EFFECT OF TWO NEWLY SYNTHESIZED RIBOFURANOSE DERIVATIVES ON THE PLASMA XANTHINE OXIDASE ACTIVITY IN PATIENTS WITH CHRONIC RENAL FAILURE

Abstract

Renal failure claims the lives of humans worldwide. Several studies suggest that oxidative stress is a major factor in deterioration of renal function. Oxidative stress seems to play a pivotal role in this process, and purine metabolism may be involved in renal failure-related oxidative stress. Xanthine oxidase is an enzyme involved in purine metabolism and is also responsible for producing reactive oxygen species.